Prevenirea cancerului prin intermediul unor programe de screening Colon cancer genetic disease Conținutul Risk factors for colorectal cancer include age, family history of colon polyps, inflammatory bowel disease and hereditary syndromes, smoking, obesity, sedentarism, alcohol consumption.
Article Introduction Colorectal cancer CRC is the third most common cancer in men and the second most common in women. Although screening, addressability and increased awareness have augmented the number of cases in the non-metastatic setting, approximately one in four individuals with CRC will be diagnosed in stage IV. Additionally, because this improvement in survival has also been associated with substantial health care financial burden, appropriate selection of patients for specific treatments is of utmost importance. Currently, there are several biomarkers that help clinicians in making the optimal treatment decision: KRAS, NRAS, BRAF mutations, human epidermal growth factor receptor 2 HER2 amplification and microsatellite instability MSI or mismatch repair MMRthey all play a significant role in the process, facilitating selection of the right treatment for the right patient.
Evidence is mounting that detecting this risk factors is a eficient way of selecting persons at high risk for colon cancer, that should undergo the screening mesures. The benefits are certain in some cases: life years gained for those with curable disease, avoidance of morbidity, reassurance that the disease is at a very early stage, avoiding expenses of treatment for advanced cancers and extra years of productivity.
Genetic Counseling and Colorectal Cancer Risk papilomatosis genital tratamiento Functia acestor gene poate fi perturbata de deletii, insertii sau rearanjamente genomice mari.
O mutatie care inactiveaza gena MMR duce la acumularea colon cancer genetic disease mutatii celulare si creste foarte mult probabilitatea de transformare maligna. Deoarece penetranta mutatiilor este incompleta, aceste anomalii genetice predispun indivizii la cancer, dar nu toti cei care le mostenesc dezvolta tumori.
What Is Your Genetic Risk for Colon Cancer?
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